ANTIBODY SIGNALING IN IMMUNITY

Maternal Anti-Dengue IgG Fucosylation Predicts Susceptibility to Dengue Disease in Infants

Sialylated IgG reduces lung inflammation and protects lung function in influenza-infected mice

What We Do

We investigate how antibody signaling regulates innate and adaptive immunity. Our research combines antibody and immune cell engineering, identification of signaling mechanisms that drive different disease outcomes, and exploration of how glycosylation of antibodies and their receptors influences immune function. By defining these pathways, we aim to enhance vaccine efficacy and develop targeted, innovative therapies.

REST expression (red) in human MDMs stimulated with IgG with increasing abundance of Fc sialylation.

Cytokine and chemokine concentrations in BAL fluid collected 4 days and 7 days post infection. Heatmaps represent the mean of

Sialylated IgG induces the transcription factor REST in alveolar macrophages to protect against lung inflammation and severe